When depression symptoms improve after starting an antidepressant, many people need to continue taking medication long term to prevent symptoms from returning. However, in some people, a particular antidepressant may simply stop working over time. Doctors don't fully understand what causes the so-called "poop-out" effect or antidepressant tolerance — known as tachyphylaxis — or why it occurs in some people and not in others. In most cases, depression symptoms get better with adjustments to medication. Your doctor may recommend that you change the dose of your current antidepressant, change to another antidepressant or add another antidepressant or other type of medication to your current treatment. Psychological counseling (psychotherapy) also may help. 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You feel better right away. “If you respond to an antidepressant very quickly, that's actually a bad sign,” Dr. Hullett says. Antidepressants work. I have been on Zoloft for 30 days now and my original psychiatrist wanted me on Paxil and I never took it and didn't go back because I lost my insurance (that was last year)... well, I ended up picking a new med this year "Zoloft" since I read what it helps and figured it would work for me, so I went to another free psychiatrist and asked him to put me on that... that psychiatrist did not have any info on my evaluations from my original psychiatrist and just gave me Zoloft and never really cared to find out about my conditions or listen to my updates or problems I was experiencing with the severe side effects. In fact; he said it was all in my head even though the emergency room and my general doctor could clearly see it was not just in my head!! At any rate, I have been experiencing so much trouble with Zoloft but thought it would get better and since I have never been on an ssri before I figured maybe I am just being a wimp after all my anxiety is getting a little better during the day and people say it gets worse before it gets better… I really should have listened to my gut instinct but I was so desperate for Zoloft to work since I have been through hell this year… I lost my biz, my home, my dad, dealt with anxiety attacks through the roof, night terrors (nocturnal panic attacks) and daily panic attacks… Let’s just say I was at the end of my rope ready to die and I started to actually vision it with great detail! – I still have a ton more scary stress coming my way and it won’t be over for another few months not to mention now I need surgery due to my gallbladder. 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Asked by Loukey Updated 4 June 2016. As WildCat said, they usually start you off on the lowest dose, and.